The interaction between cytochrome c and trans-[PtCl2(NH3)2]
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 11,p. 2223-2226
- https://doi.org/10.1039/dt9960002223
Abstract
The reaction between cytochrome c and trans-[PtCl2(NH3)2] has been studied under different conditions. The complex can not only bind to a Met-80 residue, which causes the Fe–S bond of ferricytochrome c to be broken, but can also induce a facile conversation of low-spin iron(III) cytochrome c to the high-spin form under mild conditions. Cytochrome c can also be cross-linked selectively by trans-[PtCl2(NH3)2]. The binding sites of the platinum complex in the protein derivatives were identified by analysis of the molar ratio of the two metals (Pt and Fe), 1H NMR and UV/VIS spectroscopy and differential-pulse voltammetry.Keywords
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