THE STRUCTURAL GENE FOR α-MANNOSIDASE-1 IN DICTYOSTELIUM DISCOIDEUM
- 29 October 1976
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 84 (2) , 159-174
- https://doi.org/10.1093/genetics/84.2.159
Abstract
We have isolated 4 independent mutations affecting α-mannosidase-1, a a developmentally regulated activity in Dictyostelium discoideum. Three of these result in a thermolabile α-mannosidase-1 activity. One mutation also affects the substrate affinity (Km) of the activity. In diploids these mutations show a gene dosage effect and are all alleles. The structural gene for α-mannosidase-1, as defined by these mutations, defines a new linkage group, linkage group VI. α-Mannosidase-1 is probably a homopolymer with subunits of 54,000 daltons.Keywords
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