The stereochemistry of nucleophilic substitution at phosphorus in P III and P V phosphetans
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 713-716
- https://doi.org/10.1039/p19720000713
Abstract
Nucleophilic substitution of the chlorine atom in 1-chloro-2,2,3,4,4-pentamethylphosphetan occurs with inversion of configuration at phosphorus. Several stereochemical cycles based on this compound and involving phosphetan 1-oxides and 1-sulphides are described. They support the generalisation that nucleophilic substitution of electro-negative groups in phosphetan oxides and sulphides occurs with retention of configuration at phosphorus.Keywords
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