Noncontraceptive estrogens and nonfatal myocardial infarction

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Abstract
Information was obtained on 107 women younger than 46 yr discharged from a hospital with a diagnosis of acute myocardial infarction [MI] . In the series there were 17 women aged 39-45 yr who were otherwise apparently healthy and had had a natural menopause, hysterectomy or tubal ligation or whose spouse had had a vasectomy. Among them, 9 (53%) were takine noncontraceptive estrogens just prior to admission. Among 34 control women, 4 (12%) were taking estrogens. The relative risk estimate, comparing estrogen users with nonusers, is 7.5, with 90% confidence limits of 2.4 and 24. All but 1 of the 17 MI subjects were cigarette smokers. While this illness is rare in most healthy young women, the risk in women older than about 38 yr who both smoke and take estrogens appears to be substantial.

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