Primary Immunization With Tetanus and Diphtheria Toxoids

Abstract
The reaction rates and immunogenicity of primary immunization with tetanus (5 flocculation [Lf] units) and diphtheria (1.5 Lf units) toxoids were evaluated in older children and adults. Eight of 42 subjects had local reactions to one or more doses of vaccine. All subjects had protective titers to tetanus and 94% to diphtheria after two injections. Titers of antitoxins were greater in younger patients; in those younger than 19 years, they were inversely related to age. (JAMA1982;248:2478-2480)