Respiratory retention and acute toxicity of furan

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Abstract
The respiratory tract retention of furan was studied in dogs as part of a broad investigation of compounds found in the vapor phase of cigarette smoke. The LD50 of furan was determined in mice and rats and the LC50 in mice. Respiratory uptake of furan was 90-95%, varying inversely with the ventilatory rate. Retention was not affected by tidal volume changes but was directly related to concentration inhaled. I.p. LD50 values were 5.2 mg/kg for rats and 7.0 mg/kg for mice. The LC50 for mice was 0.12 .mu.g/ml. Apparently, furan is highly toxic and it is readily absorbed by the inhalation route.

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