Functional promoter polymorphism of the human serotonin transporter
- 1 January 1997
- journal article
- research article
- Published by Wolters Kluwer Health in Psychiatric Genetics
- Vol. 7 (1) , 45-48
- https://doi.org/10.1097/00041444-199700710-00008
Abstract
To probe the hypothesis of a role for a functionally relevant 44 hp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combined n = 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combined n = 169). The fact that no difference could be observed (χ2 analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.Keywords
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