Capillary gas chromatographic determination of cyclizine and dipipanone in biological fluids
- 1 January 1988
- journal article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 113 (3) , 385-388
- https://doi.org/10.1039/an9881300385
Abstract
A capillary column gas chromatographic. method for the simultaneous determination of cyclizine and dipipanone in blood and urine is described, which has a detection limit for both drugs of 1 ng ml–1. Cyclizine and dipipanone can both be extracted from alkaline media using diethyl ether with efficiencies ranging from 88 to 98% and from 73 to 93%, respectively. The relative standard deviations for the method, applied to whole blood containing both drugs in the concentration range 2–10 ng ml–1, are 4–20% for dipipanone and 4–35% for cyclizine.Keywords
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