Characterization and distribution of HLA‐B*5002 in a Spanish population sample
- 1 August 1998
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 52 (2) , 183-186
- https://doi.org/10.1111/j.1399-0039.1998.tb02283.x
Abstract
HLA-B45, in contrast to B44, does not show molecular polymorphism. We have found a group of Caucasian Spanish individuals, serologically typed as B45, showing an unexpected HLA-B12 PCR-SSO subtyping pattern. Complete coding region sequencing and B45 subtyping by PCR-SSO demonstrated that the B45 serologic specificity is constituted by two molecular alleles: B*4501 and B*5002. B*5002 is recognized by polyclonal and monoclonal allosera against B12 and B45, whereas it is not detected by B21, B49, or B50 reagents, providing a new example of poor correlation between serology and structure. B*5002 explains an important subset (18%) of the B45-positive individuals of the Spanish population studied, and almost half are included in a very infrequent haplotypic association, Cw6-B*5002-DRB1*0406-DQA1*03-DQB1*0402.Keywords
This publication has 10 references indexed in Scilit:
- Complete coding regions of two novel HLA‐B alleles detected by prototyping (PCR‐SSP) in the British Caucasoid population: B*5108 and B*5002Tissue Antigens, 1997
- Nomenclature for factors of the HLA system, 1996Tissue Antigens, 1997
- HLA-B44 subtyping in a Spanish population: further evidence of Caucasian population diversityTissue Antigens, 1997
- HLA-BB∗1303Human Immunology, 1996
- HLA Class I nucleotide sequences, 1995Tissue Antigens, 1995
- Comprehensive, serologically equivalent DNA typing for HLA‐B by PCR using sequence‐specific primers (PCR‐SSP)Tissue Antigens, 1995
- Characterization of natural peptide ligands for HLA‐B*4402 and ‐B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA‐B44 heavy chainTissue Antigens, 1994
- Polymorphisme HLA-DRB1 et HLA-DQB1 dans la population algérienne originaire d'AlgerRevue Française de Transfusion Et D'hémobiologie, 1993
- Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix.The Journal of Immunology, 1992
- The HLA-A,B "negative" mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon.The Journal of Immunology, 1992