Usefulness of the Two-Compartment Open Model in Pharmacokinetics
- 1 March 1971
- journal article
- research article
- Published by JSTOR in Journal of the American Statistical Association
- Vol. 66 (333) , 49
- https://doi.org/10.2307/2284845
Abstract
Compartment models are widely used in pharmaceutical research to quontitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed. This discussion shows that, in spite of the extreme simplification and obvious weaknesses of this model, it has properties that make it a useful tool in drug research when properly used.Keywords
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