Effect of 6n-prophylthiouracil on Lethal Seizures in Mice.

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Abstract
The effects of feeding 0.1% 6-n-propylthiouracil in the food for nine days to an inbred strain of mice, DBA/2, recognized for its high susceptibility to sound-induced convulsive lethal seizures, were observed. Drug feeding was started at 21 days of age in 151 mice and at 25 days in 30 mice. The animals were tested for sound-induced seizures at 30 days when the susceptibility was normally highest. Practically 100% protection from lethal seizures was produced by the goiterogen. Approx. 68% of mice showed no form of convulsion. The 32% which had some form of convulsive spasm did not show the severe seizures exhibited by the controls. In this convulsive group influence of the drug was manifested by a temporary paralysis of the front legs, causing hopping movements, or the behavior took the form of a trance-cataleptic posture which lasted for 2-3 min. Also the spasmic convulsion was shortened in duration and the preconvulsive period was lengthened.

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