Effect of intravasal copper on the fertility of rats

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Abstract
Cu wire was inserted into the vas deferens and its effect on the reproductive system and fertility performance of rats was investigated. The Cu wire was 100% effective as a contraceptive for up to 4 mo. if placed correctly, and resulted in decapitation of most of the spermatozoa. No differences between the rats with an intravasal Cu wire and sham-operated controls were found for the weights of the gonads and accessory sex glands or for protein, RNA, DNA and fructose concentrations. The intravasal Cu device appears to be promising for the development of a long-term method for male contraception.