Effect of Calcium-Channel Blockers on Renal Function in Renal-Graft Recipients Treated with Cyclosporine
- 23 May 1991
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 324 (21) , 1517
- https://doi.org/10.1056/nejm199105233242122
Abstract
Nephrotoxicity is a serious side effect of cyclosporine therapy1 that appears to be caused by arteriolar vasoconstriction due to local release of thromboxane A2.2 , 3 Calcium-channel blockers have the capacity to interfere with renal vasoconstriction caused by cyclosporine,4 and by this mechanism might mitigate cyclosporine nephrotoxicity.Keywords
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