Zur Pathogenese der Arzneimittelagranulocytose

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Abstract
In two patients who were sensitive to amido-pyrine, the drug caused granulopenia and a shock-like state. Spontaneous recovery occurred in a few hours. One of the patients developed panmyelopathy and splenomegaly after the 5th dose of amidopyrine. Cortisone caused a reduction in the size of the spleen and leucopenia became less severe. The changes following the use of amidopyrine included the appearance of substances in the serum leading to agglutination of leucocytes and also damage to the bone marrow. The causes of these changes are discussed. The clinical picture is similar to that in anaphylactic shock.