THE BENEFICIAL EFFECT OF A PROSTAGLANDIN 12 ANALOG ON ISCHEMIC RAT LIVER
- 1 December 1991
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 52 (6) , 979-983
- https://doi.org/10.1097/00007890-199112000-00008
Abstract
This study was undertaken to determine whether or not prostaglandin I2 (PGI2) analog pretreatment could successfully preserve organ viability after warm hepatic ischemia in rats. Although 120-min ischemia of the liver did not permit survival in rats administered normal saline solution (NS group) before warm ischemia, the survival rate of PGI2 analogue (500 ng/kg/min)—treated rats (PG group) significantly improved to 57% (PPi) ratio measured by 31P nuclear magnetic resonance, a marked increase in the serum asparate aminotransferase (SAST) level, and an increase in the malondialdehyde (MDA) level in liver tissue. In the PG group, the B-ATP/Pi ratio was significantly improved (PP2 analog reduces warm ischemic injury of the liver and provides greater protection for organs to be transplanted.Keywords
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