The application of gene therapy in autoimmune diseases
- 1 January 2000
- journal article
- review article
- Published by Springer Nature in Gene Therapy
- Vol. 7 (1) , 9-13
- https://doi.org/10.1038/sj.gt.3301111
Abstract
The application of gene therapy in autoimmune disease represents a novel use of this technology. The goal of gene therapy in the treatment of autoimmune disease is to restore ‘immune homeostasis’ by countering the pro-inflammatory effects of the CD4+ T cells in the lesions of autoimmunity. This can be accomplished by adoptive therapy with transduced T cells which can specifically home to the site of inflammation and secrete ‘regulatory’ protein(s) to ameliorate the inflammation or by direct targeting of the retroviral vector to activated T cells in the sites of inflammation. Transduction of autoantigen recognizing CD4+ T cells, to secrete anti-inflammatory products, may become the ‘magic bullet’ to combat the ravages of autoimmune inflammation and tissue destruction.Keywords
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