DNA-protein complexes
- 1 May 1994
- journal article
- research article
- Published by Springer Nature in Applied Biochemistry and Biotechnology
- Vol. 47 (2-3) , 305-315
- https://doi.org/10.1007/bf02787942
Abstract
Sera of patients with different types of leukemia and acquired immune deficiency syndrome (AIDS) have been examined for the presence of the anti-DNA antibodies. DNA-hydrolyzing activity of antibodies was detected in the sera of patients with chronic lymphoid leukemia (CLL), pre-B-cell acute lymphoid leukemia (pre-B-All), acute myeloleukosis (AML), and AIDS in stages III and IV of the disease. In immunofluorescence tests, the DNA-hydrolyzing antibodies reacted preferentially with proliferating cell nuclei compared with resting cells. A 35-kDa factor was identified as the target for the DNA antibodies in the cell nuclei. The DNA-hydrolyzing antibody fraction from the serum of an AIDS patient crossreacted with HIV I virus proteins gp160, gp120, and p65.Keywords
This publication has 8 references indexed in Scilit:
- DNA Hydrolyzing AutoantibodiesScience, 1992
- Catalytic AntibodiesAnnual Review of Immunology, 1990
- Catalytic Hydrolysis of Vasoactive Intestinal Peptide by Human AutoantibodyScience, 1989
- Immunochemistry of DNAInternational Reviews of Immunology, 1989
- Catalytic AntibodiesScience, 1986
- An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatinCell, 1982
- Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.1968
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968