Effect of platelet activating factor on the kinetics of LDL oxidation in vitro

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Abstract
Oxidatively modified low‐density‐lipoprotein (LDL) might contribute to the atherosclerotic process. This study was performed to examine an effect of platelet‐activating factor (PAF) and of synthetic PAF analogs on Cu(II) induced oxidation of LDL in vitro: The d‐ and l‐isomers of PAF and analogs with short‐chain sn‐2‐substituents, 1‐O‐alkyl‐2‐butyryl‐sn‐glycero‐3‐phosphocholine and 1‐O‐alkyl‐2‐heptanoyl‐sn‐glycero‐3‐phosphocholine, were found to be the most effective inhibitors of LDL oxidation. Oxidation was inhibited completely at PAF concentrations above 100 μM. Lyso‐PAF and analogs carrying longer chains at the sn‐2 position were less effective. These results thus provide evidence for the involvement of other parameters in LDL oxidation beyond the content of natural antioxidants like vitamin E and β‐carotene.

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