Deficiency in suppressor T cell activity in aged animals. Reconstitution of this activity by interleukin 2.
Open Access
- 1 June 1983
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 157 (6) , 2184-2189
- https://doi.org/10.1084/jem.157.6.2184
Abstract
Spleen cells derived from aged (30 mo) C57Bl/6 mice are shown to be deficient in the ability to generate suppressor cell activity in vitro. The addition of IL-2 to cultures containing aged cells restores this function to a large extent.Keywords
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