Alternative editing of cytochrome c oxidase III mRNA in trypanosome mitochondria generates protein diversity
Open Access
- 29 September 2006
- journal article
- Published by European Molecular Biology Organization in EMBO Reports
- Vol. 7 (11) , 1128-1133
- https://doi.org/10.1038/sj.embor.7400817
Abstract
Trypanosomes use RNA editing to produce most functional mitochondrial messenger RNA. Precise insertion and deletion of hundreds of uridines is necessary to make full‐length cytochrome c oxidase III (COXIII) mRNA. We show that COXIII mRNA can be alternatively edited by a mechanism using an alternative guide RNA to make a stable mRNA. This alternatively edited mRNA is translated to produce a unique protein that fractionates with mitochondrial membranes and colocalizes with mitochondrial proteins in situ . Alternative RNA editing represents a previously unknown mechanism generating protein diversity and, as such, represents an important function for RNA editing.Keywords
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