Clinical Pharmacology, Therapeutic Use and Potential of COMT Inhibitors in Parkinson???s Disease
- 1 June 2000
- journal article
- review article
- Published by Springer Nature in Drugs
- Vol. 59 (6) , 1233-1250
- https://doi.org/10.2165/00003495-200059060-00004
Abstract
When peripheral decarboxylation is blocked by carbidopa or benserazide, the main metabolic pathway of levodopa is O-methylation by catechol- O-methyltransferase (COMT). Entacapone and tolcapone are...Keywords
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