Correlation between molecular clock ticking, codon usage, fidelity of DNA repair, chromosome banding and chromatin compactness in germline cells
- 15 June 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 217 (2) , 184-186
- https://doi.org/10.1016/0014-5793(87)80660-9
Abstract
The vertebrate genome is built of long DNA regions, relatively homogeneous in GC content, which likely correspond to bands on stained chromosomes. Large differences in composition have been found among DNA regions belonging to the same genome. They are paralleled by differences in codon usage in genes differently localized. The hypothesis presented here asserts that these differences in composition are caused by different mutational bias of α and β DNA polymerases, these polymerases being involved to different extents in the repair of DNA lesions in compact and relaxed chromatin, respectively, in germline cells.Keywords
This publication has 23 references indexed in Scilit:
- Two Distinct Compositional Classes of Vertebrate Gene-Bearing DNA Stretches, Their Structures and Possible Evolutionary OriginDNA, 1987
- A cell-cycle-dependent DNA polymerase activity that replicates intact DNA in chromatinJournal of Molecular Biology, 1986
- CpG-rich islands and the function of DNA methylationNature, 1986
- SELECTED TOPICS IN CHROMATIN STRUCTUREAnnual Review of Genetics, 1985
- Replication Timing of Genes and Middle Repetitive SequencesScience, 1984
- Characterization of Giemsa dark- and light-band DNACell, 1982
- Fidelity of Mammalian DNA PolymerasesScience, 1981
- The DNA Components of the Chicken GenomeEuropean Journal of Biochemistry, 1979
- An analysis of eukaryotic genomes by density gradient centrifugationJournal of Molecular Biology, 1976
- Deoxyribonucleic acid replication in synchronized cultured mammalian cells: I. Time of synthesis of molecules of different average guanine + cytosine contentJournal of Molecular Biology, 1970