Meningiomas. A Light and Electron Microscopy Study

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Abstract
A morphological and ultrastructural study was undertaken from a personal series of meningiomas. Especially the fine structure of the tumour has been described by the electron microscopic study of 16 meningotheliomatous and 4 fibroblastic meningiomas. In all cases, it was possible to distinguish certain cells with epithelial features such as desmosomes, microfilaments and interdigitating extensions. Also the cytological patterns of fibroblastic meningiomas usually were similar to the meningotheliomatous type, anyhow the intercellular space between the interdigitating extensions of adjacent cells was occupied by collagen-fibers. At present, it has been impossible to demonstrate the capability of the tumour cells to synthetize collagen. Since the tumour cells of both the meningiomas are substantially similar to the subarachnoid space meningocyte, it is concluded that the neoplasm rises from a cell with double potentiality for fibroblastic and epithelial differentiation.