VITAMIN A STUDIES IN CASES OF KERATOSIS FOLLICULARIS (DARIER'S DISEASE)

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Abstract
In 1941 Peck, Chargin and Sobotka1published their preliminary report on investigations which led them to the conclusion that keratosis follicularis (Darier's disease) is a vitamin A deficiency syndrome. The present paper embodies extended observations on 10 cases of this disease. Four of the cases were reported in our first paper, and in 3 of them continued observation was possible. MATERIALS AND METHODS A quantitative estimation of vitamin A in the blood serum was carried out by Dr. Susan Kann with a photoelectric colorimeter according to the method of Carr and Price.2The lower normal limits obtained with this method are variously given as 60 to 90 U. S. P. units of vitamin A per hundred cubic centimeters of blood serum. In cases 1, 3, 4, 8 and 9 Dr. Selig Hecht, of the department of biophysics of Columbia University, used his excellent method of determining dark adaptation

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