Adenylate cyclase in lean and obese (ob/ob) mouse epididymal white adipocytes
- 30 September 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 58 (10) , 1033-1038
- https://doi.org/10.1139/o80-140
Abstract
The defect in catecholamine-stimulated adenylate cyclase which is characteristic of the ob/ob mouse apparently is associated with a decrease in the sensitivity of the system to guanine nucleotides (guanosine 5''-[.beta..gamma.-imido]triphosphate and GTP). No difference in the .beta.-adrenergic receptor activity was found between the lean and obese mice on the basis of their capacity to bind the .beta.-adrenergic antagonist [3H]dihydroalprenolol. A defect in the activation of the adenylate cyclase by .beta.-adrenergic agents may reside in the guanyl nucleotide binding site(s).This publication has 13 references indexed in Scilit:
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