Crystal Growth of Cephalothin Sodium in Frozen Solution. II. Effects of Amount of Seed, Concentration, and Temperature

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Abstract
The growth rate of cephalothin sodium (KF) after seeding in frozen solution was measured. Crystal growth of KF followed the equation until .alpha. = 0.98. 1- (1-.alpha.)1/3 = (1/3N)(Kt)N where .alpha. is crystallinity, K is rate constant, t is time and N is parameter depending on the freezing temperature and the amount of seed. Crystal growth of KF in the frozen solution hardly changed when the concentration of KF was in the range 19.4%-28.6% but it was remarkably dependent on the amount of seed at the constant freezing temperature. According to the decrease in the amount of seed at the constant freezing temperature, the value of N increased and the K decreased. The growth rate increased with a rise of freezing temperature, and had the maximum value at a temperature little below the eutectic temperature. The activation energy of crystal growth of KF in the range of -5.degree.-14.degree. C was 49 kcal/mol.

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