Enoxacin-warfarin interaction: Pharmacokinetic and stereochemical aspects

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Abstract
The interaction between the new quinoline‐azaquinoline antibiotic enoxacin and the oral anticoagulant warfarin was investigated in six healthy male volunteers. Enoxacin was found not to affect the hypoprothrombinemic response produced by warfarin but did produce a decrease in the clearance of the less pharmacologically potent enantiomer of warfarin, (R)‐warfarin. The decreased clearance of (R)‐warfarin produced by concomitant enoxacin administration was found to be a consequence of inhibition by enoxacin of the (R)‐6‐hydroxywarfarin metabolic pathway. Clinical Pharmacology and Therapeutics (1987) 42, 33–41; doi:10.1038/clpt.1987.104