Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism in guinea pig pulmonary arteries.
- 1 January 1989
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 51 (2) , 302-305
- https://doi.org/10.1254/jjp.51.302
Abstract
We have attempted to clarify whether or not captopril and 1Sar-8lle-angiotensin II could protect isoproterenol-induced facilitation of norepinephrine release in guinea pig pulmonary arteries loaded with 3H-norepinephrine. Angiotensin I at 1 nM and 30 nM isoproterenol similarly facilitated evoked release of 3H-norepinephrine at 1 Hz. Captopril at 1 .mu.M and 1Sar-8lle-angiotensin II at 10 nM completely prevented angiotensin I-induced facilitation, whereas these pretreatments produced no effect on isoproterenol-induced facilitation. Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism.This publication has 0 references indexed in Scilit: