Cerium-catalyzed α-Oxidation of β-Dicarbonyl Compounds with Molecular Oxygen
- 1 December 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (01) , 0119-0121
- https://doi.org/10.1055/s-2002-19331
Abstract
β-Ketoesters and β-diketones are α-hydroxylated by molecular oxygen in the presence of 5 mol% CeCl3·7 H2O in i-PrOH as solvent. The method is limited to substrates with an α-alkyl substituent. Optimal yields are achieved with cyclic starting materials.Keywords
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