Non-Genetic Variations in Salivary Isoagglutinin Titers

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Abstract
Several hypotheses have been offered in explanation of the erratic appearance of blood group isoagglutinins in saliva. All theories have involved antibody "secretor" and "nonsecretor" alleles at one or more genetic loci. Investigations on salivas of 120 subjects over a 10-week period using a new technique indicate that the incidence of isoagglutinin secretion can be raised virtually to 100% in persons of all blood types if followed through time. Individual titers may fluctuate from negative to as high as 1:128. Various circumstances (e. g. salivary pH, seaons, temperature, and individual immunologic history) appear to determine intensity of secretion rather than any discernable genetic directives. These antibodies may be manufactured locally, stimulated by the presence of oral bacteria, and cross-react with blood group antigens.

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