Maternal serum α‐fetoprotein and low birth weight in relation to gestational age

Abstract
Summary. To determine when in the first and second trimester a raised serum α‐fetoprotein (AFP) level best predicts low birth weight a case‐control study was performed on 157 singleton low birth‐weight (2.5 kg) and 314 singleton control pregnancies (birth weight >2.5 kg). The association between raised maternal serum AFP and low birth weight was confirmed, but there was no special time in pregnancy before 29 weeks gestation when a raised AFP level predicted low birth weight materially better than at any other time.

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