Antibodies to β-bungarotoxin and its phospholipase inactive derivative
- 22 June 1982
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 215 (1200) , 365-373
- https://doi.org/10.1098/rspb.1982.0047
Abstract
Antisera were raised against the presynaptic neurotoxin .beta.-bungarotoxin and against its phospholipase-inactive derivative, modified by reaction with p-bromophenacyl bromide. The cross-reactivity of the antisera to other phospholipase A2 enzymes and polypeptide neurotoxins was examined. The antisera inhibited the neurotoxic effects of .beta.-bungarotoxin at the frog motor endplate and the enzymatic activity of the toxin on model phospholipid membranes, although it was unlikely that the catalytic active center was the locus of any major determinant.Keywords
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