Taurine Protects against Oxidant-Induced Lung Injury: Possible Mechanism(s) of Action

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Abstract
Ozone (O3) is one of the six major air pollutants for which National Ambient Air Quality Standards have been designated under the Clean Air Act (8). Ozone is the most prevalent photochemical oxidant and an important component of “smog”. Ozone has been demonstrated to elicit the release of bronchoactive chemical mediators and to induce inflammation in the lungs of various species, including humans. Although the precise mechanism(s) of lung injury induced by O3 is unknown, this oxidant gas may interact directly with tissues, can generate free radicals, and clearly produces a lung inflammatory response.