PLASMA-RENIN ACTIVITY AND ANGIOTENSIN-II DURING ORAL CONTRACEPTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 9  (6) , 346-349
Abstract
Plasma renin activity (PRA) and angiotensin II (A II) concentrations were measured in the 1st and 2nd half of the menstrual cycle for 4 mo. in 27 healthy young women, in 3 groups. During month II and III, group I received lynestrenol 0.5 mg, group II lynestrenol 0.5 mg + ethinyl estradiol 0.05 mg and group III d-norgestrel 0.25 mg + ethinyl estradiol 0.05 mg as contraceptive treatment. In group I no changes of PRA or A II were observed. In group II and III both PRA and A II rose significantly during oral contraceptive treatment. Progestagens may offer an advantage as they do not stimulate the renin-angiotensin axis.

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