The Role of Iodine in the Pathogenesis of Thyroid Enlargement in Rats with Chronic Renal Failure

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Abstract
In rats with mild renal failure produced by a 2/3 nephrectomy on one side followed by a total nephrectomy on the other, ingestion of a high (10 mg/kg) I diet for 2 mo. resulted in thyromegaly, high serum I levels and a good correlation between thyroid weight and serum I (r = 0.75, P < 0.01) or thyroid weight and blood urea nitrogen (r = 0.745, P < 0.01). I may potentiate the effects of unidentified goitrogens that accumulate in rats with renal failure. Since the serum I levels were higher in the animals with renal failure, it is also possible that I alone may have been responsible for the observed differences in thyroid weight.

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