Suppression of renal disease and arthritis, and prolongation of survival in MRL‐lpr mice treated with an extract of tripterygium wilfordii hook F

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Abstract
Objective. Treatment of MRL-lpr/lpr mice with Tripterygium wilfordii Hook f (TWHf) to evaluate its effects on mortality, renal disease, and arthritis. Methods. Mice were fed water (group A, control), TWHf (group B), or first water and then TWHf (group C) from age 7 weeks until age 21 weeks. Results. Arthritis and glomerulonephritis were decreased in groups B and C mice, and survival was increased in group B mice. Conclusion. TWHf decreases the mortality rate, and severity of glomerulonephritis and arthritis in MRL-Ipr/lpr mice.