The effects of 2′- and 3′-alkyl substituents on oligonucleotide hybridization and stability
- 1 August 1994
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 4 (16) , 1969-1974
- https://doi.org/10.1016/s0960-894x(01)80545-x
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexesBiochemistry, 1993
- Current concepts in antisense drug designJournal of Medicinal Chemistry, 1993
- Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne PyrimidinesScience, 1993
- Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targetsJournal of Medicinal Chemistry, 1993
- 2'-O-alkyl oligoribonucleotides as antisense probes.Proceedings of the National Academy of Sciences, 1990
- Antisense oligonucleotides: a new therapeutic principleChemical Reviews, 1990
- Highly efficient chemical synthesis of 2′-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleasesNucleic Acids Research, 1989
- Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotidesNucleic Acids Research, 1987
- How flexible is the furanose ring? 1. A comparison of experimental and theoretical studiesJournal of the American Chemical Society, 1982
- Nucleoside conformation is determined by the electronegativity of the sugar substituentNucleic Acids Research, 1980