Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.

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Abstract
Somatic cell hybrids between mouse myeloma cells and IARC-BL2 Burkitt lymphoma human cells carrying a t(8;22) chromosome translocation were studied for the presence and expression of human Ig .lambda. chains and for the c-myc oncogene. Apparently, the c-myc oncogene remains on the 8q+ chromosome, and the excluded and rearranged C.lambda. allele translocates from chromosome 22 to this chromosome 8. As a result of the translocation, transcriptional activation of the c-myc oncogene on the rearranged chromosome 8 (8q+) occurs, while the c-myc oncogene in the normal chromosome 8 is transcriptionally silent. The translocation of a rearranged Ig locus to the 3'' side of an unrearranged c-myc oncogene may enhance its transcription and contribute to malignant transformation.