Studies on the activities of tannins and related compounds from medicinal plants and drugs. VI. Inhibitory effects of caffeoylquinic acids on histamine release from rat peritoneal mast cells.

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Abstract
The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia spp. [A. princeps and A. montana] on the histamine release from rat mast cells induced by compound 48/80 [p-methoxy-N-methylphenethylamine formaldehyde condensation product] and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 .times. 10-5 M, caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48-/80-induced hstamine release from mast cells. Caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10-5 M.

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