Human recombinant interleukin‐4 inhibits lymphokine‐activated killer activity of sheep erythrocyte rosette‐forming (E+) and ‐non‐forming (E−) human lymphocytes

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Abstract
The effect of human recombinant interleukin‐4 (rIL‐4) on lymphokine‐activated killer activity (LAK) of peripheral blood lymphocytes (PBL) as well as sheep erythrocyte rosette‐forming (E+) and ‐non‐forming (E–) lymphocytes stimulated by human recombinant interleukin‐2 (rIL‐2) has been investigated. rIL‐4 drastically inhibited LAK activity of PBL cultured for 18 hr and for 5 days in the presence of rIL‐2. Distribution of T, B and IgG Fc‐receptor‐bearing lymphocytes, as assessed by immunofluorescence and flow cytometry, was no different at the end of the culture in the presence of rIL‐2 plus rIL‐4 than with rIL‐2 alone. LAK activity of E+ and E– lymphocytes was similarly inhibited. Finally, rIL‐4 did not affect the natural killer (NK) activity of rIL‐2‐activated PBL as assessed by the capacity of these cells to kill the appropriate NK target.

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