Influence of the central nervous system on fetal lung development. Experimental study.
Open Access
- 1 December 1977
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 52 (12) , 965-967
- https://doi.org/10.1136/adc.52.12.965
Abstract
Upper cervical cord injury was produced in fetal rabbits at 22-26 days' gestation. In 11 setuses with severe cord injury delivered at 28-29 days' gestation there was a median reduction in lung weight (expressed as a proportion of body weight) of 43% and a median reduction in estimated total lung DNA of 16% in comparison with paired operated littermates with intact cords. The hypoplastic lungs showed collapse on histology; if cord damage had been inflicted before 24 days' gestation there was retarded maturation. We conclude that the central nervous system plays a vital role in fetal lung growth and maturation, probably by maintenance of fetal respiratory movements.This publication has 10 references indexed in Scilit:
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