Blood Flow in the Rabbit Sinus Mucosa During Experimentally Induced Chronic Sinusitis

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Abstract
Chronic sinusitis was induced in New Zealand White rabbits. Access to the sinus cavity in question was obtained through a hole drilled in the dorsum of the nose, and for induction of sinusitis either cotton wool together with a suspension of 108 Streptococcus pneumoniae was introduced, or this method was combined with blocking of the sinus ostium with methacrylate. In 9 rabbits (weight range 3.6–5.0 kg), blood flow was determined 5 weeks-9 months after the induction of sinusitis, at a point in time when heavy inflammatory signs were present. The blood flow was determined both with radioactively labelled microspheres 16±1.5 μm in diameter and with Rb86Cl. Cardiac output as determined with the microsphere method was 127±28 mlxmin-1x1000 g-1. The blood flow in the sinus mucosa was 0.60±0.16 mlxmin-1xg-1 with the microsphere method and 0.51±0.20 mlxmin-1xg-1 with use of Rb86Cl. These values did not differ significantly from the corresponding values found previously in healthy rabbits.