Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy
Open Access
- 1 March 1994
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 38 (3) , 628-631
- https://doi.org/10.1128/aac.38.3.628
Abstract
We studied the impact of zidovudine (AZT) in Cas-Br-M murine leukemia virus-infected NFS-N mice after administration by once-daily bolus or continuous infusion. While higher peak concentrations of AZT were achieved by once-daily dosing, continuous AZT infusion at 25 micrograms/h maintained levels > 1 microM in plasma and > 0.2 microM in the brain. Continuous infusion provided significantly better viral inhibition, even though total doses were only one-third that of the once-daily therapy group.Keywords
This publication has 14 references indexed in Scilit:
- Use of a Neonatal Murine Retrovirus Model To Evaluate the Long-Term Efficacy and Toxicity of Antiviral AgentsAnnals of the New York Academy of Sciences, 1990
- Central Nervous System Effects of Human Immunodeficiency Virus Type 1Annual Review of Medicine, 1990
- High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patientsNature, 1990
- Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virusAntimicrobial Agents and Chemotherapy, 1989
- Human Immunodeficiency Virus in Vacuolar Myelopathy of the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1988
- Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1985
- LAGRAN program for area and moments in pharmacokinetic analysisComputer Programs in Biomedicine, 1983
- “Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein AAnalytical Biochemistry, 1981
- Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equationsJournal of Pharmacokinetics and Biopharmaceutics, 1978
- Plaque assay techniques for murine leukemia virusesVirology, 1970