Alleles of the Ly-17 alloantigen define polymorphisms of the murine IgG Fc receptor.

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Abstract
Antibodies specific for allelic determinants of the cell membrane alloantigen Ly-17 were found to react with genetically determined polymorphic sites on the murine IgG Fc receptor (Fc.gamma.R). Monoclonal antibodies specific for Ly-17.2 and the Fc.gamma.R detected identical populations of cells in thymus, spleen, lymph node, and bone marrow and had nearly identical reactivity with a large number of hematopoietic neoplasms. Antibodies to the Fc.gamma.R and either allele of Ly-17 blocked binding of rabbit IgG dimers to the Fc.gamma.R on spleen and bone marrow cells. Antibodies to the Fe.gamma.R also blocked binding of antibodies to either allele of Ly-17, whereas anti-LY-17 antibodies only partially blocked the binding of antibodies to the Fc.gamma.R. Biochemical studies showed that antibodies to Ly-17 and the Fc.gamma.R precipitated proteins of Mr 55,000-60,000. The identity of the proteins recognized by these antibodies was confirmed by sequential immunoprecipitation.

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