Macrophage migration inhibitory factor and glucocorticoid sensitivity
Open Access
- 16 May 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 45 (8) , 937-943
- https://doi.org/10.1093/rheumatology/kel142
Abstract
Glucocorticoids (GCs) are widely used in the treatment of inflammatory diseases including rheumatoid arthritis (RA). Treatment with GC is associated with significant dose-dependent side-effects. The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has emerged in recent years as a candidate factor which could regulate GC sensitivity. MIF is induced by GC, and is able to override anti-inflammatory actions of GCs. In this review, we summarize the pro-inflammatory actions of MIF with respect to RA, describe the interactions between MIF and GC and examine new evidence, which identifies MIF as a specific target for steroid sparing.Keywords
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