Zolpidem Intoxication Mimicking Narcotic Overdose: Response to Flumazenil
- 1 March 1990
- journal article
- case report
- Published by SAGE Publications in Human & Experimental Toxicology
- Vol. 9 (2) , 105-107
- https://doi.org/10.1177/096032719000900209
Abstract
Zolpidem is a recently introduced sleep-inducer which is thought to act on the central-type benzodiazepine receptors. This observation is the first report of drug poisoning with this compound. The toxic response was characterized by the development of a profound but short-lasting coma, associated with pin-point pupils and respiratory depression, as observed in a narcotic overdose. These clinical signs were not influenced by the administration of naloxone, but responded dramatically to flumazenil. Some analytical data on zolpidem toxicokinetics are presented.Keywords
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