Effect of surface coating on platelet count drop during cardiopulmonary bypass

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Abstract
This study was designed to investigate the effect of surface coating on platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing open-heart surgery were randomly divided into three groups each receiving a different type of coated hollow-fiber membrane oxygenator. The patients were given either an uncoated oxygenator (noncoated group), an oxygenator coated with Carmeda® (Carmeda group) or an uncoated oxygenator with albumin in the priming solution (albumin group). Comparisons were made in platelet count pre-CPB, on bypass (15-25 min) and during the warming period. Calculations were used to account for the effect of hemodilution. The albumin group had significantly lower platelet count drops (-4.8 ± 7.1%) than the Carmeda group (11.0 ± 8.3%) and the noncoated group (20.3 ± 14.5%). Carmeda surface coating demonstrated some beneficial effects, but to a lesser degree than the albumin.