POINT OF ACTION OF 3-O-TOLOXY-1,2-PROPANEDIOL (LISSEPHEN®) AND EFFECTS ON NERVOUS SYSTEM

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Abstract
WHILE studying the pharmacologic properties of α-substituted ethers of glycerol, Berger and Bradley1 observed that certain of these compounds caused paralysis with profound muscular relaxation, and a sleeplike condition from which the animals could be roused. Paralysis was followed by complete recovery. The most potent and the safest of all the compounds examined, and the drug with the widest margin of safety between the paralyzing and the lethal dose, was 3-o-toloxy-1,2-propanediol, the o-tolyl ether of glycerol. It was said to have a curare-like action, but with a greater factor of safety. The drug was suggested by Mallinson2 as a useful agent in anesthesia. He published his experience and results in 112 cases. He found it to have a greater margin of safety than curare. Doses of 7 to 28 mg. per kilogram of body weight produced no undesirable effects in man. This observation is not unexpected, since 200

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