Ectopic ACTH Syndrome in APUD Tumors

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Abstract
Rapidly progressing hypercorticism was observed in 2 patients with malignant neoplasms, a 72 yr old man with anaplastic small cell carcinoma and a 48 yr old woman with a primary aupdoma of the liver. Both patients were treated with chemotherapy in conventional doses. Both patients developed acute dyspnea and sudden death, 7 and 10 days, respectively, after chemotherapy [cyclophosphamide and vincristine and adriamycin] was given. The possibility that patients with ectopic ACTH secretion are excessively vulnerable to chemotherapy is raised and judicious management urged.

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