Immunohistochemical and electron microscopic demonstration of human papillomavirus in dysplasia of the uterine cervix.

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Abstract
TOKI, T., OIKAWA, N., TASE, T., SATO, S., WADA, Y., YAJIMA, A. and HIGASHIIWAI, H. Immunohistochemical and Electron Microscopic Demonstration of Human Papillomavirus in Dysplasia of the Uterine Cervix. Tohoku J. exp. Med., 1986, 149 (2), 163-167 - Twenty-five cases of dysplasia of the uterine cervix were studied for the presence of human papillomavirus (HPV) by means of immunohistochemical and electron microscopic techniques. Serial sections of the same histological specimen were examined in each case. HPV was detected in 14 cases by both immunohistochemistry and electron microscopy, while 10 cases were negative with both methods. In only one case, there was a discrepancy in the results derived from these two methods. It was concluded that the relation between HPV infection and cervical dysplasia was confirmed and that immunohistochemical and electron microscopic methods led almost to the same result in detecting HPV in cervical dysplasia.